Azole Resistance of Aspergillus fumigatus in Immunocompromised Patients with Invasive Aspergillosis
نویسندگان
چکیده
Author affiliations: Groupe Hospitalier Saint-Louis-LariboisièreFernand-Widal, Assistance Publique-Hôpitaux de Paris, Paris, France (A. Alanio, B. Denis, S. Hamane, E. Raffoux, R. Peffault de Latour, J. Menotti, S. Amorim, S. Touratier, A. Bergeron, S. Bretagne); Université Paris Diderot, Sorbonne Paris Cité, Paris (A. Alanio, R. Peffault de Latour, J. Menotti, S. Amorim, A. Bergeron, S. Bretagne); National Reference Center of Invasive Mycoses and Antifungals, Institut Pasteur, Paris (A. Alanio, S. Bretagne); Le Centre National de la Recherche Scientifique URA 3012, Paris (A. Alanio, J. Menotti, S. Bretagne)
منابع مشابه
Nationwide Surveillance of Azole Resistance in Aspergillus Diseases.
Aspergillus disease affects a broad patient population, from patients with asthma to immunocompromised patients. Azole resistance has been increasingly reported in both clinical and environmental Aspergillus strains. The prevalence and clinical impact of azole resistance in different patient populations are currently unclear. This 1-year prospective multicenter cohort study aimed to provide det...
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As the incidence of azole resistance in Aspergillus fumigatus is rising and the diagnosis of invasive aspergillosis (IA) in immunocompromised patients is rarely based on positive culture yield, we screened our Aspergillus DNA sample collection for the occurrence of azole resistance mediating cyp51 A key mutations. Using two established, a modified and a novel polymerase chain reaction (PCR) ass...
متن کاملAzole Resistance of Aspergillus fumigatus in Immunocompromised Patients with Invasive Aspergillosis
malignancies. J Antimicrob Chemother. 2011;66:371–4. http://dx.doi.org/10.1093/jac/dkq450 4. De Pauw B, Walsh TJ, Donnelly JP, Stevens DA, Edwards JE, Calandra T, et al. Revised definitions of invasive fungal disease from the European Organization for Research and Treatment of Cancer/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycos...
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BACKGROUND Azole resistance is an emerging problem in Aspergillus fumigatus and complicates the management of patients with Aspergillus-related diseases. Selection of azole resistance may occur through exposure to azole fungicides in the environment. In the Netherlands a surveillance network was used to investigate the epidemiology of resistance selection in A. fumigatus. METHODS Clinical A. ...
متن کاملAzole resistance surveillance in Aspergillus fumigatus: beneficial or biased?
Azole resistance is a growing concern with Aspergillus fumigatus, and may cause increased mortality in patients with azole-resistant invasive aspergillosis (IA). Microbial surveillance has been recognized as a fundamental component of resistance management. Surveillance information may be used to inform decisions regarding health services and research funding allocation, to guide local infectio...
متن کاملمروری بر پیدایش مقاومت به داروهای گروه آزولی در آسپرژیلوس فومیگاتوس
Invasive Aspergillosis (IA) is an important cause of mortality and morbidity in the immunocompromised host such as, neutropenic individuals, chronic granulomatous disorder, leukemia, those undergoing solid organ transplantation, patients using broad spectrum antibiotics and steroids, patients with severe underlying diseases and patients with chronic pulmonary obstructive disease are among the m...
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عنوان ژورنال:
دوره 22 شماره
صفحات -
تاریخ انتشار 2016